- the chemicals used for the TB test are typically made up of TUBERSOL® and Phenol (a preservative - see the toxicological profile for Phenol)
- TUBERSOL® is a known mutagen
- the CDC states that TB testing is safe during pregnancy, even though there has never been any mutagenicity testing performed and Tubersol is a known mutagen
- according to the 1972 edition of Encyclopedia and Dictionary of Medicine and nursing defines Phenol as "an extremely poisonous antiseptic, germicidal, and disinfectant"
- Phenol is associated with skin cancer development when injected in animals
- the CDC states that the TB testing is safe, even though no carcinogenicity studies have been performed
- targeted TB testing in health care workers is only recommended (not required) by the CDC; although some facilities make testing mandatory amongst employees (and subject to termination for refusal)
- "Animal reproduction studies have not been conducted with TUBERSOL. It is also not known whether TUBERSOL can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. TUBERSOL should be given to a pregnant woman only if clearly needed."
- 85% of guideline authors have some sort of relationships with drug companies, and they are often not disclosed
- 38% of respondents said they had served as employees or consultants for drug companies; 58% received research money
- 59% had links with drug companies whose medications were considered in the particular guidelines they authored, almost all cases predating the guideline creation process
- These numbers may be even greater, as only 52% of authors responded
Also worth mentioning:
Another interesting document I came across indicates that the current limit values for Phenol were set over 40 years ago(5). The document states that the limit values need to be reconsidered because research indicates that Phenol is harmful even at very low levels in animal experiments. In addition to serving as a preservative in TB testing, phenol is used in plastic and dyes (and is frequently used in childrens toys and our food packaging).
2) N.K. Choudhry, et. al. Relationships between authors of clinical practice guidelines and the pharmaceutical industry JAMA; 287,612-617, 2002